Retinoids Help Normalize KeratinizationAlthough the mechanism by which topical and systemic retinoids help restore acne follicles to a healthy state is unknown, it has been well demonstrated that they normalize keratinization within the infundibular region of the follicle, so that shed follicular cells slough to the surface of the skin rather than clump together and obstruct the pores.After exposure to retinoids, follicular cells actually turn over more rapidly than they would in a pre-acne state.Retinoic acid has a high affinity for the gamma retinoid receptors, which are believed to be integral to the pathogenesis of acne.In addition to their ability to reverse abnormal keratinization within the follicle, the topical retinoids - especially adapalene (Differin®), a naphthoic acid derivative - may have anti-inflammatory properties and thus may address two factors involved in the development of acne.
And after 3 days my skin was much, much clearer, and stayed acne-free for about a week. But guess what?
You see, by putting something on your acne, like creams and lotions, you simply cannot expect to see much difference if you suffer from stubborn acne. And that's because acne is caused by conditions within the body. This means only an internal, natural approach will EVER work to clear up your breakouts...
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